Signs and Evidence

Making clinical sense of scientific data

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Cluster headache

Calculated pretest-probability: 0.57 %
Relevant inclusion criteria: Primary headache Calculate probabilities!

Clinical signs

Lacrimation during headache
 Positive likelihood ratio
99.55 ( Uluduz D et al. )
(average) 99.55
Negative likelihood ratio
0.46 ( Uluduz D et al. )
(average) 0.46
Phonophobia
 Positive likelihood ratio
2.32 ( Uluduz D et al. )
(average) 2.32
Negative likelihood ratio
0.71 ( Uluduz D et al. )
(average) 0.71
Photophobia
 Positive likelihood ratio
2.09 ( Uluduz D et al. )
(average) 2.09
Negative likelihood ratio
0.78 ( Uluduz D et al. )
(average) 0.78
Nausea
 Positive likelihood ratio
2.01 ( Uluduz D et al. )
(average) 2.01
Negative likelihood ratio
0.76 ( Uluduz D et al. )
(average) 0.76
Vomiting
 Positive likelihood ratio
1.85 ( Uluduz D et al. )
(average) 1.85
Negative likelihood ratio
0.90 ( Uluduz D et al. )
(average) 0.9

Sources used:

1.Uluduz D et al. Cranial autonomic features in migraine and migrainous features in cluster headache. Arch Neuropsychiatr 2016; 53
2.Stovner LJ et al. Prevalence of headache in Europe: a review for the Eurolight project. J Headache Pain (2010) 11:289–299