Signs and Evidence

Making clinical sense of scientific data


Beware of the limitations of this tool

B-lactam allergy

Calculated pretest probability: 13.55 %
Relevant inclusion criteria: All adults 


1Reporting history of this allergy

To further investigations

Sources used:

1.Salkind AR et al. Is This Patient Allergic to Penicillin? An Evidence-Based Analysis of the Likelihood of Penicillin Allergy. JAMA, May 16, 2001—Vol 285, No. 19. 2498 - 2505
2.Sodhi M et al. Is it safe to use carbapenems in patients with a history of allergy to penicillin? Journal of Antimicrobial Chemotherapy, Volume 54, Issue 6, 1 December 2004, Pages 1155–1157
3.Siles RI et al. Allergy blood testing: A practical guide for clinicians. Cleveland Clinic Journal of Medicine. 2011 September;78(9):585-592
4.Shah NS et al. Documenting Penicillin Allergy: The Impact of Inconsistency. PLoS One. 2016; 11(3): e0150514
5.Albin S et al. Prevalence and Characteristics of Penicillin Allergy in Urban Adults. J allergy clin immunol volume 131, number 2