Signs and Evidence

Making clinical sense of scientific data

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HIV infection

Clinical signs

Genital ulcer
 Positive likelihood ratio
5.40 ( Wood E et al. )
(average) 5.40
Negative likelihood ratio
0.99 ( Wood E et al. )
(average) 0.99
Vomiting
 Positive likelihood ratio
4.60 ( Wood E et al. )
(average) 4.60
Negative likelihood ratio
0.90 ( Wood E et al. )
(average) 0.9
Diarrhea
 Positive likelihood ratio
3.70 ( Wood E et al. )
(average) 3.70
Negative likelihood ratio
0.88 ( Wood E et al. )
(average) 0.88
Oral ulcer
 Positive likelihood ratio
3.40 ( Wood E et al. )
(average) 3.40
Negative likelihood ratio
0.91 ( Wood E et al. )
(average) 0.91
Nausea
 Positive likelihood ratio
3.20 ( Wood E et al. )
(average) 3.20
Negative likelihood ratio
0.97 ( Wood E et al. )
(average) 0.97
Lymphadenopathy - any
 Positive likelihood ratio
3.10 ( Wood E et al. )
(average) 3.10
Negative likelihood ratio
0.70 ( Wood E et al. )
(average) 0.7
Fatigue - tired
 Positive likelihood ratio
2.60 ( Wood E et al. )
(average) 2.60
Negative likelihood ratio
0.85 ( Wood E et al. )
(average) 0.85
Headache
 Positive likelihood ratio
2.10 ( Wood E et al. )
(average) 2.10
Negative likelihood ratio
0.90 ( Wood E et al. )
(average) 0.9

Sources used:

1.Wood E et al. Does this adult patient have early HIV infection?: The Rational Clinical Examination systematic review. JAMA. 2014 Jul 16;312(3):278-85