Signs and Evidence

Making clinical sense of scientific data

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Fatigue - tired

Upper respiratory infection
 Positive likelihood ratio
0.90 ( Nader Shaikh et al. )
(average) 0.9
Negative likelihood ratio
1.28 ( Nader Shaikh et al. )
(average) 1.28
Mononucleosis
 Positive likelihood ratio
1.20 ( Mark H et al. )
(average) 1.2
Negative likelihood ratio
0.30 ( Mark H et al. )
(average) 0.3
Hypothyroidism
 Positive likelihood ratio
1.96 ( Carle A et al. )
(average) 1.96
Negative likelihood ratio
0.33 ( Carle A et al. )
(average) 0.33
HIV infection
 Positive likelihood ratio
2.60 ( Wood E et al. )
(average) 2.6
Negative likelihood ratio
0.85 ( Wood E et al. )
(average) 0.85


Sources used:

1.Nader Shaikh et al. Signs and Symptoms that Differentiate Acute Sinusitis from Viral Upper Respiratory Tract Infection. Pediatr Infect Dis J. 2013 Oct; 32(10): 1061–1065.
2.Mark H et al. Epstein-Barr Virus Infectious Mononucleosis. Am Fam Physician. 2004 Oct 1;70(7):1279-1287.
3.Carle A et al. Hypothyroid symptoms and the likelihood of overt thyroid failure: a population-based case–control study. Eur J Endocrinol. 2014 Nov;171(5):593-602
4.Wood E et al. Does this adult patient have early HIV infection?: The Rational Clinical Examination systematic review. JAMA. 2014 Jul 16;312(3):278-85