Signs and Evidence

Making clinical sense of scientific data

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Nausea

Cholecystitis
 Positive likelihood ratio
1.10 ( Trowbridge RL et al. )
(average) 1.1
Negative likelihood ratio
0.80 ( Trowbridge RL et al. )
(average) 0.8
Cholelithiasis
 Positive likelihood ratio
1.20 ( Abraham S et al. )
(average) 1.2
Negative likelihood ratio
0.74 ( Abraham S et al. )
(average) 0.74
HIV infection
 Positive likelihood ratio
3.20 ( Wood E et al. )
(average) 3.2
Negative likelihood ratio
0.97 ( Wood E et al. )
(average) 0.97
Appendicitis
 Positive likelihood ratio
7.00 ( Idris SA et al. )
(average) 7
Negative likelihood ratio
0.10 ( Idris SA et al. )
(average) 0.1
Migraine
 Positive likelihood ratio
19.20 ( Smetana GW et al. )
(average) 19.2
Negative likelihood ratio
0.20 ( Smetana GW et al. )
(average) 0.2
Cluster headache
 Positive likelihood ratio
2.01 ( Uluduz D et al. )
(average) 2.01
Negative likelihood ratio
0.76 ( Uluduz D et al. )
(average) 0.76
Acute coronary syndrome
 Positive likelihood ratio
1.88 ( Mant J et al. )
(average) 1.88
Negative likelihood ratio
0.77 ( Mant J et al. )
(average) 0.77


Sources used:

1.Trowbridge RL et al. Does This Patient Have Acute Cholecystitis? JAMA, January 1, 2003—Vol 289, No. 1 80-86
2.Abraham S et al. Surgical and Nonsurgical Management of Gallstones. Am Fam Physician. 2014 May 15;89(10):795-802
3.Wood E et al. Does this adult patient have early HIV infection?: The Rational Clinical Examination systematic review. JAMA. 2014 Jul 16;312(3):278-85
4.Idris SA et al. The sensitivity and specificity of the conventional symptoms and signs in making adiagnosis of acute appendicitis. Sudan journal of medical sciences. 4. 55-61
5.Smetana GW et al. The Diagnostic Value of Historical Features in Primary Headache SyndromesA Comprehensive Review. Arch Intern Med. 2000;160(18):2729-2737
6.Uluduz D et al. Cranial autonomic features in migraine and migrainous features in cluster headache. Arch Neuropsychiatr 2016; 53
7.Mant J et al. Systematic review and modelling of the investigation of acute and chronic chest pain presenting in primary care. Health Technology Assessment Volume: 8, Issue: 2, Published in February 2004