Signs and Evidence

Making clinical sense of scientific data

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Wheezing

Asthma in children
 Positive likelihood ratio
8.10 ( ITS Yu et al. )
(average) 8.1
Negative likelihood ratio
0.44 ( ITS Yu et al. )
(average) 0.44
Asthma in adults
 Positive likelihood ratio
2.29 ( Tomita K et al. )
(average) 2.29
Negative likelihood ratio
0.80 ( Tomita K et al. )
(average) 0.8
COPD
 Positive likelihood ratio
3.80 ( Dewar M et al. )
(average) 3.8
Negative likelihood ratio
0.66 ( Dewar M et al. )
(average) 0.66
Hypothyroidism
 Positive likelihood ratio
2.20 ( Carle A et al. )
(average) 2.2
Negative likelihood ratio
0.83 ( Carle A et al. )
(average) 0.83


Sources used:

1.ITS Yu et al. Using child reported respiratory symptoms to diagnose asthma in the community. Arch Dis Child 2004;89:544–548.
2.Tomita K et al. A scoring algorithm for predicting the presence of adult asthma: a prospective derivation study. Prim Care Respir J. 2013 Mar;22(1):51-8
3.Dewar M et al. Chronic Obstructive Pulmonary Disease: Diagnostic Considerations. Am Fam Physician. 2006 Feb 15;73(4):669-676
4.Carle A et al. Hypothyroid symptoms and the likelihood of overt thyroid failure: a population-based case–control study. Eur J Endocrinol. 2014 Nov;171(5):593-602